Leading COVID-19 vaccine prospects depend on brand-new innovations that have fast-tracked advancement and screening. Vaccines from Pfizer and Moderna have actually finished early stage 3 medical trials and are apparently under evaluation at the United States FDA for emergency situation usage permission (EUA) although security continues. This video describes the concepts underlying the leading DNA, messenger RNA (mRNA), and viral vector vaccine prospects, and how they may cause resistance to SARS-CoV-2 infection.
0: 00 Introduction
1: 21 Traditional vaccines
2: 00 COVID-19 vaccine key ins advancement
2: 18 Making vaccines from a hereditary series
2: 45 Target antigen: the S protein
3: 32 Genetic vaccines (DNA and mRNA)
4: 18 Moderna/NIH and Pfizer/BioNTech vaccines
4: 52 Viral vector vaccines
5: 42 Adenovirus vectors (University of Oxford/AstraZeneca and Johnson & Johnson/Janssen Pharmaceuticals)
6: 32 rVSV vector vaccine (Merck/IAVI)
7: 15 Previous experience with next generation vaccines
7: 50 Importance of Phase 3 Trials
For complete livestreams included in this video:
Anthony S. Fauci, MD, January 27, 2020: https://youtu.be/3qlagdc_luM
Paul A. Offit, MD, June 1, 2020: https://youtu.be/2DUiBlj5rsQ
Robert Redfield, MD, July 14, 2020: https://youtu.be/jzHIhSZ_fiA
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