Leading COVID-19 vaccine prospects count on brand-new technologies that have fast-tracked advancement and testing. Vaccines from Pfizer and Moderna have actually completed early stage 3 medical trials and are reportedly under evaluation at the United States FDA for emergency situation use authorization (EUA) although safety surveillance continues. This video explains the principles underlying the leading DNA, messenger RNA (mRNA), and viral vector vaccine prospects, and how they may induce immunity to SARS-CoV-2 infection.
0: 00 Introduction
1: 21 Standard vaccines
2: 00 COVID-19 vaccine key ins advancement
2: 18 Making vaccines from a genetic series
2: 45 Target antigen: the S protein
3: 32 Hereditary vaccines (DNA and mRNA)
4: 18 Moderna/NIH and Pfizer/BioNTech vaccines
4: 52 Viral vector vaccines
5: 42 Adenovirus vectors (University of Oxford/AstraZeneca and Johnson & Johnson/Janssen Pharmaceuticals)
6: 32 rVSV vector vaccine (Merck/IAVI)
7: 15 Previous experience with next generation vaccines
7: 50 Importance of Stage 3 Trials
For full livestreams featured in this video:
Anthony S. Fauci, MD, January 27, 2020: https://youtu.be/3qlagdc_luM
Paul A. Offit, MD, June 1, 2020: https://youtu.be/2DUiBlj5rsQ
Robert Redfield, MD, July 14, 2020: https://youtu.be/jzHIhSZ_fiA
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